Supplementary Applications

one technology - many possibilities

The following applications have been performed with Geniom® Technology.
We are currently not marketing these applications as full solutions.
In case of specific interest please contact us.

ChIP-on-chip

Chromatin ImmunoPrecipitation on Geniom Biochips is an application used to determine in vivo DNA binding sites for any given protein in any genomic region of interest, resulting in high resolution maps of interactions between DNA-associated proteins and DNA of any given species.

Geniom Technology allows you to

  • perform microarray based Chromatin ImmunoPrecipitation approaches for precise mapping of protein binding sites.
  • quickly identify sequences that are involved in interactions with DNA binding proteins such as histones, transcription factors, RNA and DNA polymerases or proteins involved in DNA breaking
  • have a customized look at interactions of DNA-binding proteins and any desired genomic target region

Geniom’s longmer arrays ensure highest sensitivity, from high-resolution tiling arrays to designs aimed at known promoter regions

Enzyme-on-Chip

Geniom Technology, for the first time, integrates the high-throughput of microarray analyses and the extraordinary sensitivity of enzymatic reactions in the micro channels of its microfluidic reaction carrier. This powerful combination transfers today’s molecular biologist’s enzyme toolbox from single test tube procedures to a versatile lab on a chip format.

The new 3’-inversed synthesis set for Geniom Biochips enables reverse (3’-up) synthesis of DNA oligonucleotides in the biochip. The emerging probes present free 3’-ends accessible to enzymes like nucleic acid polymerases, thus providing a broad spectrum of new applications for DNA microarrays, like PCR-on-chip and Primer extension reactions.

Epigenetic Profiling

Identify DNA methylation patterns with fast and reliable results for any CpG site. Supported by powerful software, Custom Geniom Biochips meet your specific question. Its unique closed microfluidic system allows reliable and reproducible results eliminating handling artifacts and protecting microarrays from environmental elements such as ozone and ambient light. The Geniom Biochip design eliminates cross-contamination by providing physical separation of 8 microarray compartments.

Genotyping

The Genoim’s unique closed microfluidic system enables reliable and reproducible results eliminating handling artifacts and protecting microarrays from environmental elements such as ozone and ambient light. The Geniom Biochip design eliminates cross-contamination by providing physical separation of 8 microarray compartments. Genioms extraordinary adaptability to up-to-date information and the easy to handle adjustments of microarray setups allow focused genotyping analyses.

Genotyping with the Geniom:

  • hybridization-based assay possible as well as enzyme enhanced approaches like allele-specific primer extension and mini sequencing
  • highly parallel single nucleotide polymorphism (SNP) analysis or de-novo genotyping
  • detect SNPs, deletions or insertions, or perform resequencing – even on the same array
  • define your probe set to ensure complete coverage of your genomic region of interest
  • mutational and comparative sequence analysis of any organism and new genetic variants
  • always up-to-date data
  • applied in genotyping studies

Virus and Pathogen Detection

  • short set-up times and very fast reaction processes by microfluidics support (in case of pandemics or spread of fast changing mutants of microorganisms or viruses)
  • always up-to-date data
  • fast, sensitive, and specific for your pathogen study
  • no limitation to fixed-content predesigned arrays
  • the in-built CCD camera facilitates dynamic detection resulting in a real-time analysis of every single reaction on the microarray
  • applied in molecular analysis of pathogens