Biomarkers

Molecular biomarkers in modern biomedicine

The value of biomarkers for diagnostic and prognostic assessments has become increasingly well established in medicine.

Technological advances especially in genomics and transcriptomics enable researchers to capture molecular fingerprints of human diseases such as cancer, and fine-tune patient classification according to the detected molecular changes.

MicroRNAs (miRNAs) are endogenous, noncoding small RNAs that negatively regulate the translation of coding messenger RNAs (mRNAs) in a sequence-specific manner. The role of miRNAs in pathogenesis and the power to associate expression changes with disease states underscores their value as molecular biomarkers.