microRNA Biomarkers - Overview
microRNA discovery and profiling with febit’s products and services
Explore febit’s technology and comprehensive service options for
- miRNA biomarker profiling in any sample: body fluids like blood, serum and urine, FFPE, fresh or frozen tissue, biopsies
- Development of disease-specific diagnostic biomarker signatures
- Analysis of target gene expression and affected pathways
- Small RNA sequencing for the discovery of novel miRNA biomarkers
- Whole transcriptome sequencing
- Identification of low-abundance miRNAs and sequence variants
- Target gene prediction based on expert bioinformatics
- Comprehensive statistical analysis of regulated networks
Equipped with the established Geniom microarray technology febit is also an official ABI service provider offering next generation sequencing on the ABI SOLiD platform as well as quantitative RT PCR on the ABI TaqMan system.
febit guarantees the most up-to-date array content: Instant access to the newest miRBase Version, 24 hours following the latest release. Currently available: miRBase 15 miRNA Biochips.
Growing number of microRNAs published in the miRBase database
Counts of miRNA entries in the miRBase as well as the number of publications pertaining to miRNA research are permanently and rapidly growing, proving that miRNA research is one of the hottest and most important topics in the field right now.
MicroRNAs (miRNAs) are endogenous, non-coding RNAs that play a fundamental role in gene regulation and have critical functions across various biological processes. Pairing to mRNAs, they have been shown to direct posttranscriptional repression by altering the stability or translational efficiency of their target mRNAs in many species.
The role of miRNAs in pathogenesis and the power to associate expression changes with disease states underscores their value as molecular biomarkers.
“It will be helpful and an advance for our research to use a whole genome microarray based on the most recent data (of the new mouse genome) available which have been published only weeks ago. This array allows the performance of a microarray expression profiling as well as a targeted Next-Generation Sequencing at the current state of the art.”
