Discover and analyze long non-coding RNAs with next generation sequencing and validated Geniom Biochips

• NGS for sequencing and quantifying of transcriptomes including long non-coding RNAs at maximal resolution and dynamic range, independent of transcript size
• Profiling of long non-coding RNAs in any species on validated Geniom Biochips

In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner, producing large numbers of long non-coding RNAs (ncRNAs). The biological significance and function of this abundant class of ncRNAs is largely unknown. But long ncRNAs have been implicated in a variety of regulatory processes, ranging from X chromosome inactivation and genomic imprinting to chromatin modification and transcriptional activation. Thus, altered long ncRNA expression is thought to be involved in human disease and many studies focus on the role of ncRNAs in pathogenesis.